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Blood vessel occlusion due to abnormal red cells

Blood vessel occlusion due to abnormal red cells
In SCD, due to the hemoglobin polymerization, red blood cells (RBC) lose their elasticity and cannot deform to pass through capillaries and cause blockages. After a process of deoxygenation, sickle RBCs become crescent shapes, rigid, and adhesive, consequently resulting in blocked blood vessels, known as vaso-occlusion. This vessel obstruction leads to painful crises, wide spread organ damage, early mortality, as well as infections, strokes, and severe pain in bones, chest, abdomen, and head.


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